• Emerging opportunities for target discovery in rare cancers

Sharifnia, T, Hong, AL, Painter, CA, Boehm JS.

Cell Chem Biol. 2017. 

Tsherniak A, Vazquez F, Montgomery PG, Weir, BA, Kryukov G, Cowley GS, Gill S, Harrington, WF, Pantel S, Krill-Burger JM, Meyers RM, Ali L, Goodale A, Lee Y, Jiang G, Hsiao J, Gerath, WFJ, Howell S, Merkel E, Ghandi M, Garraway LA, Root DE*, Golub TR*, Boehm JS*, Hahn WC*.

Cell. 2017. PMID: 28753430

*These authors contributed equally

  • progress towards precision functional genomics in cancer

Johanessen CM, Boehm JS.

Curr Opin Syst Biol. 2017. 

  • Systematic morphological profiling of human gene and allele function via Cell Painting

Rohban MHSingh SWu XBerthet JBBray MAShrestha YVarelas XBoehm JSCarpenter AE.

Elife. 2017. PMID: 28315521

  • High-throughput Phenotyping of Lung Cancer Somatic Mutations

Berger AH, Brooks AN, Wu X, Shrestha Y., Chouinard C, Piccioni F, Bagul M, Kamburov A, Imielinski M, Hogstrom L, Zhu C, Yang X, Pantel S, Sakai R, Watson J, Kaplan N, Campbell JD, Singh S, Root DE, Narayan R, Natoli T, Lahr DL, Tirosh I, Tamayo P, Getz G, Wong B, Doench J, Subramanian A, Golub TR, Meyerson M, Boehm JS.

Cancer Cell. 2016. PMID: 27478040

  • Integrated genetic and pharmacologic interrogation of rare cancers

Hong ALTseng YYCowley GSJonas OCheah JHKynnap BDDoshi MBOh CMeyer SCChurch AJGill SBielski CMKeskula PImamovic AHowell SKryukov GVClemons PATsherniak AVazquez FCrompton BDShamji AFRodriguez-Galindo CJaneway KARoberts CWStegmaier Kvan Hummelen PCima MJLanger RSGarraway LASchreiber SLRoot DEHahn WCBoehm JS.

Nat Commun. 2016. PMID: 27329820

Kim EIlic NShrestha YZou LKamburov AZhu CYang XLubonja RTran NNguyen CLawrence MSPiccioni FBagul MDoench JGChouinard CRWu XHogstrom LNatoli TTamayo PHorn HCorsello SMLage KRoot DESubramanian AGolub TRGetz GBoehm JSHahn WC

Cancer Discov. 2016. PMID: 27147599

  • Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

Rosenbluh JMercer JShrestha YOliver RTamayo PDoench JGTirosh IPiccioni FHartenian EHorn HFagbami LRoot DEJaffe JLage KBoehm JSHahn WC.

Cell Syst. 2016. PMID: 27684187

Lohr JG, Adalsteinsson VA, Cibulskis K, Choudhury AD, Rosenberg M, Cruz-Gordillo P, Francis JM, Zhang CZ, Shalek AK, Satija R, Trombetta JJ, Lu D, Tallapragada N, Tahirova N, Kim S, Blumenstiel B, Sougnez C, Lowe A, Wong B, Auclair D, Van Allen EM, Nakabayashi M, Lis RT, Lee GS, Li T, Chabot MS, Ly A, Taplin ME, Clancy TE, Loda M, Regev A, Meyerson M, Hahn WC, Kantoff PW, Golub TR, **Getz G, **Boehm JS, **Love JC.

Nat Biotechnol. 2014. PMID: 24752078

**These senior authors contributed equally

 

 

Dunn GP, Cheung HW, Agarwalla PK, Thomas S, Zektser Y, Karst AM, Boehm JS, Weir BA, Berlin AM, Zou L, Getz G, Liu JF, Hirsch M, Vazquez F, Root DE, Beroukhim R, Drapkin R, Hahn WC.

Proc Natl Acad Sci U S A. 2014, PMID: 24385586

 

Yang X, *Boehm JS, Yang X, Salehi-Ashtiani K, Hao T, Shen Y, Lubonja R, Thomas SR, Alkan O, Bhimdi T, Green TM, Johannessen CM, Silver SJ, Nguyen C, Murray RR, Hieronymus H, Balcha D, Fan C, Lin C, Ghamsari L, Vidal M, Hahn WC, Hill DE, Root DE.

Nat Methods. 2011, PMID: 21706014

*These authors contributed equally

*Cheung HW, *Cowley GS, *Weir BA, *Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, Gopal S, Tamayo P, Gould J, Tsherniak A, Stransky N, Luo B, Ren Y, Drapkin R, Bhatia SN, Mesirov JP, Garraway LA, Meyerson M, Lander ES, Root DE, Hahn WC.

Proc Natl Acad Sci U S A. 2011. PMID: 21746896

*These authors contributed equally

Boehm JS, Hahn WC.

Nat Rev Genet. 2011. PMID: 21681210

*Johannessen CM, *Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA.

Nature. 2010. PMID: 21107320

*These authors contributed equally

Moody SE, Boehm JS, Barbie DA, Hahn WC.

Curr Opin Mol Ther. 2010. PMID: 20521217

Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC.

Nature. 2009. PMID: 19847166

Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC.

Cell. 2007. PMID: 17574021

Boehm JS, Hession MT, Bulmer SE, Hahn WC.

Mol Cell Biol. 2005. PMID: 16024784

Boehm JS, Hahn WC.

Cytotechnology. 2004. PMID: 19003243